CELIAC DISEASE CONSORTIUM

News

Results of CDC research:

CDC researchers (underlined) contributed to a Nature Genetics publication:

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

David A van Heel, Lude Franke, Karen A Hunt, Rhian Gwilliam, Alexandra Zhernakova, Mike Inouye, Martin C Wapenaar, Martin C N M Barnardo, Graeme Bethel, Geoffrey K T Holmes, Con Feighery, Derek Jewell,
Dermot Kelleher, Parveen Kumar, Simon Travis, Julian RF Walters, David S Sanders, Peter Howdle, Jill Swift, Raymond J Playford, William M McLaren, M Luisa Mearin, Chris J Mulder, Ross McManus, Ralph McGinnis, Lon R Cardon, Panos Deloukas & Cisca Wijmenga

NATURE GENETICS ADVANCE ONLINE PUBLICATION 10 June 2007

Summary:

In this study 310,605 SNPs were tested for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. The association was independently confirmed in two further collections suggesting that genetic variation in this region predisposes to celiac disease.

Press release (Dutch):  http://www.umcg.nl/azg/nl/nieuws/persberichten/124094