Publications CDC

RESULTS

updated June 2009

1. Arentz-Hansen H, Fleckenstein B, Molberg O, Scott H, Koning F, Jung G, Roepstorff P, Lundin KEA, Sollid LM. The molecular basis for oat intolerance in patients with Celiac disease. Plos Medicine 2004;1:84-92.

2. Diosdado B, Wapenaar MC, Franke L, Duran KJ, Goerres MJ, Hadithi M, Crusius JB, Meijer JW, Duggan DJ, Mulder CJ, Holstege FC, Wijmenga C. A microarray screen for novel candidate genes in coeliac disease pathogenesis. Gut 2004;53:944-951.

3. Franke L, van Bakel H, Diosdado BA, van Belzen M, Wapenaar M, Wijmenga C. TEAM: a tool for the integration of expression, and linkage and association maps. European Journal of Human Genetics 2004;12:633-638.

4. Gremmen B. Plant Genomics and the Precautionary Principle. Genomics for Biosafety in Plant Biotechnology 2004;NATO science Series I: Life and Behavioural Sciences – vol. 359, IOS Press:223.

5. Gremmen B. Intrinsic value and plant genomics. In: J.De Tavernier and S.Aerts, ed. Science, Ethics and Society. Leuven: 2004:145-148.

6. Koning F. De Immunologie van Coeliakie. Tijdschrift voor Kindergeneeskunde 2004;74:6-11.

7. Schweizer JJ, von Blomberg BM, Bueno-de Mesquita HB, Mearin ML. Coeliac disease in The Netherlands. Scandinavian Journal of Gastroenterology 2004;39:359-364.

8. Spaenij-Dekking EH, Kooy-Winkelaar EM, Nieuwenhuizen WF, Drijfhout JW, Koning F. A novel and sensitive method for the detection of T cell stimulatory epitopes of alpha/beta- and gamma-gliadin. Gut 2004;53:1267-1273.

9. van Belzen MJ, Houwen RHJ, Wijmenga C, Mulder CJ. The genetic puzzle of celiac disease - Reply. Gastroenterology 2004;126:1217.

10. van Belzen MJ, Vrolijk MM, Meijer JWR, Crusius JBA, Pearson PL, Sandkuijl LA, Houwen RHJ, Wijmenga C. A genomewide screen in a four-generation Dutch family with celiac disease: Evidence for linkage to chromosomes 6 and 9. American Journal of Gastroenterology 2004;99:466-471.

11. van Belzen MJ, Mulder CJJ, Zhernakova A, Pearson PL, Houwen RHJ, Wijmenga C. CTLA4+49 A/G and CT60 polymorphisms in Dutch coeliac disease patients. European Journal of Human Genetics 2004;12:782-785.

12. van Belzen MJ, Koeleman BP, Crusius JB, Meijer JW, Bardoel AF, Pearson PL, Sandkuijl LA, Houwen RH, Wijmenga C. Defining the contribution of the HLA region to cis DQ2-positive coeliac disease patients. Genes and Immunity 2004;5:215-220.

13. Van Belzen M, Mearin ML, Wijmenga C. Coeliac disease, a complex interplay between genes, food and environment. In: Poortman Y SRKC, ed. The increasing role of nutrition and genomics in the prevention and management of disease. Soesterberg: Aspekt bv/VSOP/WAO, 2004:51-60.

14. Wapenaar MC, Monsuur AJ, Wijmenga C. De erfelijke aspecten van Coeliakie. Tijdschrift voor Kindergeneeskunde 2004;72:11-16.

15. Wapenaar MC, van Belzen MJ, Fransen JH, Sarasqueta AF, Houwen RH, Meijer JW, Mulder CJ, Wijmenga C. The interferon gamma gene in celiac disease: augmented expression correlates with tissue damage but no evidence for genetic susceptibility. Journal of Autoimmunity 2004;23:183-190.

16. Wijmenga C, van Belzen M, Diosdado B, Franke L, Monsuur A, van Oort E, Wapenaar M, Houwen R, Mulder C. A functional-genetics approach to unravel molecular pathways in celiac disease. Gastroenterology 2004;126:A246.

17. Collin P, Kaukinen K, Vogelsang H, Korponay-Szabo I, Sommer R, Schreier E, Volta U, Granito A, Veronesi L, Mascart F, Ocmant A, Ivarsson A, Lagerqvist C, Burgin-Wolff A, Hadziselimovic F, Furlano RI, Sidler MA, Mulder CJ, Goerres MS, Mearin ML, Ninaber MK, Gudmand-Hoyer E, Fabiani E, Catassi C, Tidlund H, Alainentalo L, Maki M. Antiendomysial and antihuman recombinant tissue transglutaminase antibodies in the diagnosis of coeliac disease: a biopsy-proven European multicentre study. Eur J Gastroenterol Hepatol 2005;17:85-91.

18. Diosdado B, Wijmenga C. Molecular mechanisms of the adaptive, innate and regulatory immune responses in the intestinal mucosa of celiac disease patients. Expert Review of Molecular Diagnostics 2005;5:681-700.

19. Diosdado B, van Oort E, Wijmenga C. "Coelionomics": towards understanding the molecular pathology of coeliac disease. Clinical Chemistry and Laboratory Medicine 2005;43:685-695.

20. Diosdado B, Stepniak DT, Monsuur AJ, Franke L, Wapenaar MC, Mearin ML, Koning F, Wijmenga C. No genetic association of the human prolyl endopeptidase gene in the Dutch celiac disease population. American Journal of Physiology-Gastrointestinal and Liver Physiology 2005;289:G495-G500.

21. Gilissen L, van Heteren G, van der Meer I, Hall R. Towards prevention of allergy through an integrated multidisciplinary approach. NJAS Wageningen Journal of Life Sciences 2005;53:35-47.

22. Hamer RJ. Coeliac Disease: background and biochemical aspects. Biotechnological Advances 2005;23:401-408.

23. Koning F, Schuppan D, Cerf-Bensussan N, Sollid LM. Pathomechanisms in celiac disease. Best Practice & Research in Clinical Gastroenterology 2005;19:373-387.

24. Koning F, Spaenij-Dekking EH. The Molecular Basis of Celiac Disease. In: Moncef Zouali, ed. Molecular Autoimmunity. Springer Science and Business Media, Inc, 2005.

25. Koning F. Celiac disease: caught between a rock and a hard place. Gastroenterology 2005;129:1294-1301.

26. Koning F, Gilissen L, Wijmenga C. Gluten: a two-edged sword. Immunopathogenesis of celiac disease. Springer Seminars in Immunopathology 2005;27:217-232.

27. Mearin ML, Ivarsson A, Dickey W. Coeliac disease: is it time for mass screening? Best Practice & Research in Clinical Gastroenterology 2005;19:441-452.

28. Mearin ML, van Geel AM, Csizmadia CGDS, Koopman HM, Hylkema HB, Schweizer JJ, Verloove-Vanhorick SP. Follow-up of children with unrecognised coeliac disease (CD) identified after mass screening. European Journal of Gastroenterology & Hepatology 2005;17:A28-A29.

29. Monsuur AJ, de Bakker PIW, Alizadeh BZ, Zhernakova A, Bevova MR, Strengman E, Franke L, van't Slot R, van Belzen MJ, Lavrijsen ICM, Diosdado B, Daly MJ, Mulder CJJ, Mearin ML, Meijer JWR, Meijer GA, van Oort E, Wapenaar MC, Koeleman BPC, Wijmenga C. Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect. Nature Genetics 2005;37:1341-1344.

30. Spaenij-Dekking L, Kooy-Winkelaar Y, van Veelen P, Drijfhout JW, Jonker H, van Soest L, Smulders MJ, Bosch D, Gilissen LJ, Koning F. Natural variation in toxicity of wheat: potential for selection of nontoxic varieties for celiac disease patients. Gastroenterology 2005;129:797-806.

31. Spaenij-Dekking L, Koning F. Natural variation in toxicity of wheat - Reply. Gastroenterology 2005;129:2129-2130.

32. Spaenij-Dekking L, Kooy-Winkelaar Y, Koning F. The ethiopian cereal tef in celiac disease. New England Journal of Medicine 2005;353:1748-1749.

33. Steens RFR, Csizmadia CGDS, George EK, Ninaber MK, Sing RAH, Mearin ML. A national prospective study on childhood celiac disease in the Netherlands 1993-2000: An increasing recognition and a changing clinical picture. Journal of Pediatrics 2005;147:239-243.

34. Stepniak D, Vader LW, Kooy Y, van Veelen PA, Moustakas A, Papandreou NA, Eliopoulos E, Drijfhout JW, Papadopoulos GK, Koning F. T-cell recognition of HLA-DQ2-bound gluten peptides can be influenced by an N-terminal proline at p-1. Immunogenetics 2005;57:8-15.

35. van Heel DA, Hunt K, Greco L, Wijmenga C. Genetics in coeliac disease. Best Practice & Research in Clinical Gastroenterology 2005;19:323-339.

36. Wapenaar MC, Wijmenga C. A combined genetics and genomics approach to unravelling molecular pathways in coeliac disease. Novartis Foundation Symposium 2005;267:113-134.

37. Zhernakova A, Eerligh P, Wijmenga C, Barrera P, Roep BO, Koeleman BPC. Differential association of the PTPN22 coding variant with autoimmune diseases in a Dutch population. Genes and Immunity 2005;6:459-461.

38. Zhernakova A, Eerligh P, Barrera P, Weseloy JZ, Huizinga TWJ, Roep BO, Wijmenga C, Koeleman BPC. CTLA4 is differentially associated with autoimmune diseases in the Dutch population. Human Genetics 2005;118:58-66.

39. Amundsen SS, Vatn M, Wijmenga C, Sollid LM, Lie BA. Association analysis of MYO9B gene polymorphisms and inflammatory bowel disease in a Norwegian cohort. Tissue Antigens 2006;68:249-252.

40. Amundsen SS, Monsuur AJ, Wapenaar MC, Lie BA, Ek J, Gudjonsdottir AH, Ascher H, Wijmenga C, Sollid LM. Association analysis of MYO9B gene polymorphisms with celiac disease in a Swedish/Norwegian cohort. Human Immunology 2006;67:341-345.

41. Curley CR, Monsuur AJ, Wapenaar MC, Rioux JD, Wijmenga C. A functional candidate screen for coeliac disease genes. Eur J Hum Genet 2006;14:1215-1222.

42. de Bakker PI, McVean G, Sabeti PC, Miretti MM, Green T, Marchini J, Ke X, Monsuur AJ, Whittaker P, Delgado M, Morrison J, Richardson A, Walsh EC, Gao X, Galver L, Hart J, Hafler DA, Pericak-Vance M, Todd JA, Daly MJ, Trowsdale J, Wijmenga C, Vyse TJ, Beck S, Murray SS, Carrington M, Gregory S, Deloukas P, Rioux JD. A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet 2006;38:1166-1172.

43. Diosdado B, Monsuur AJ, Mearin ML, Mulder C, Wijmenga C. The downstream modulator of interferon-gamma, STAT1 is not genetically associated to the Dutch coeliac disease population. European Journal of Human Genetics 2006;[Epub ahead of print].

44. Fiers MWEJ, Kleter GA, Peijnenburg AACM, Nijland H, Nap JP, van Ham CHJ. In silico prediction of potential allergenicity of proteins according to the FAO/WHO guidelines with the help of AllermatchTM. In: Gilissen LJWJ, Wichers HJSHFJ, and Bogers RJ, eds. Allergy Matters: New Approaches to Allergy Prevention and Management. Springer, 2006.

45. Franke L, van Bakel H, Fokkens L, de Jong ED, Egmont-Petersen M, Wijmenga C. Reconstruction of a functional human gene network, with an application for prioritizing positional candidate genes. American Journal of Human Genetics 2006;78:1011-1025.

46. Gilissen LJWJ, Bolhaar STHP, Knulst AC, Zuidmeer L, Van Ree R, Gao ZS, Van de Weg WE. Production of hypoallergenic plant foods by selection, breeding and genetic modification. In: Gilissen LJWJ, Wichers HJSHFJ, and Bogers RJ, eds. Allergy Matters: New Approaches to Allergy Prevention and Management. Springer, 2006.

47. Gilissen LJWJ, Wichers HJSHFJ, Bogers RJ. Allergy Matters: New Approaches to Allergy Prevention and Management. Springer. 2006.

48. Gilissen LJWJ, Wichers HJSHFJ, Beers G. Future developments in allergy prevention: a matter of integrating medical, natural and social sciences. In: Gilissen LJWJ, Wichers HJSHFJ, and Bogers RJ, eds. Allergy Matters: New Approaches to Allergy Prevention and Management. 2006:1-8.

49. Hunt KA, Monsuur AJ, McArdle W, Kumar PJ, Travis SPL, Walters JRF, Jewell DP, Strachan DP, Playford RJ, Wijmenga C, van Heel DA. Lack of association of MYO9B genetic variants with coeliac disease in a British cohort. Gut 2006;55:969-972.

50. Monsuur AJ, Stepniak D, Diosdado B, Wapenaar MC, Mearin ML, Koning F, Wijmenga C. Genetic and functional analysis of pyroglutamyl-peptidase I in coeliac disease. Eur J Gastroenterol Hepatol 2006;18:637-644.

51. Monsuur AJ, Wijmenga C. Understanding the molecular basis of celiac disease: what genetic studies reveal. Ann Med 2006;38:578-591.

52. Schenk MF, Fischer ARH, Frewer LJ, Gilissen LJWJ, Jacobsen E, Smulders MJM. Attitude towards GM application as for prevention of hey fever and food allergy by patients and non-patients. 2006.

53. Stepniak D, Koning F. Celiac disease- Sandwiched between innate and adaptive immunity. Human Immunology 2006;67:460-468.

54. Stepniak D, Spaenij-Dekking L, Mitea C, Moester M, de Ru A, Baak-Pablo R, van Veelen P, Edens L, Koning F. Highly efficient gluten degradation with a newly identified prolyl endoprotease: implications for celiac disease. Am J Physiol Gastrointest Liver Physiol 2006;291:G621-G629.

55. Stepniak D, Koning F. Enzymatic gluten detoxification: the proof of the pudding is in the eating! Trends in Biotechnology 2006;24:433-434.

56. van Bodegraven AA, Curley CR, Hunt KA, Monsuur AJ, Linskens RK, Onnie CM, Crusius JB, Annese V, Latiano A, Silverberg MS, Bitton A, Fisher SA, Steinhart AH, Forbes A, Sanderson J, Prescott NJ, Strachan DP, Playford RJ, Mathew CG, Wijmenga C, Daly MJ, Rioux JD, van Heel DA. Genetic variation in myosin IXB is associated with ulcerative colitis. Gastroenterology 2006;131:1768-1774.

57. van Herpen TWJM, Goryunova SV, van der Schoot J, Mitreva M, Salentijn E, Vorst O, Schenk MF, van Veelen PA, Koning F, van Soest LJM, Vosman B, Bosch D, Hamer RJ, Gilissen LJWJ, Smulders MJM. Alpha-gliadin genes from the A, B, and D genomes of wheat contain different sets of celiac disease epitopes. Bmc Genomics 2006;7:1-13.

58. van Putten MC, Frewer LJ, Gilissen LJWJ, Gremmen B, Peijnenburg AACM, Wichers HJ. Novel foods and food allergies: A review of the issues. Trends in Food Science & Technology 2006;17:289-299.

59. Van Putten MC, Schenk MF, Gremmen B, Frewer LJ. Consumers, communication and food allergy. In: Frewer LJ and van Trijp H, eds. Understanding Consumer of Food Products. Woodhead Publishers, 2006.

60. Zhernakova A, Alizadeh BZ, Eerligh P, Hanifi-Moghaddam P, Schloot NC, Diosdado B, Wijmenga C, Roep BO, Koeleman BP. Genetic variants of RANTES are associated with serum RANTES level and protection for type 1 diabetes. Genes Immun 2006.

61. Alizadeh BZ, Valdigem G, Coenen MJH, Zhernakova A, Franke B, Monsuur A, van Riel PLCM, Barrera P, Radstake TRDJ, Roep BO, Wijmenga C, Koeleman BPC. Association analysis of functional variants of the FcgRIIa and FcgRIIIa genes with type 1 diabetes, celiac disease and rheumatoid arthritis. Human Molecular Genetics 2007;16:2552-2559.

62. Diosdado B, van Bakel H, Strengman E, Franke L, van Oort E, Mulder CJ, Wijmenga C, Wapenaar MC. Neutrophil recruitment and barrier impairment in celiac disease: A genomic study. Clinical Gastroenterology and Hepatology 2007;5:574-581.

63. Gilissen LJWJ, van der Meer IM, Smulders MJM. Beyond celiac disease toxicity: Detoxified and non-toxic grains. In: Fasano A, Troncone R, and Branski D, eds. New frontiers in Celiac Disease. Basel: Karger, 2007.

64. Hamer R, Abecassis J, Weegels P. C&E Spring Meeting - Consumer driven cereal innovation: Where science meets industry - Montpellier, France, May 2-4 2007. Cereal Foods World 2007;52:S2.

65. Hamer RJ, van Herpen TW. Studies on the Relation between Glutenin Particles and Protein Bodies . In: Lookhart GL, ed. Gluten Proteins 2006. St. Paul, Minnesota: AAAC International, 2007:218-221.

66. Hoffmann-Sommergruber K, Sancho A, Gilissen LJWJ. Identifying fruit, nut and vegetable cultivars with low allergen levels and effects of post-harvest treatments. In: Mills ENC, ed. Managing Allergens in Food – From Farm to Table (in press). 2007.

67. Hopman GD, von Blomberg BME, Kooy-Winkelaar EMC, Morreau J, Koning F, Lamers CBHW, Mearin ML. Gluten tolerance in coeliac disease patients. European Journal of Gastroenterology & Hepatology 2007;19:A15.

68. Hopman GD, Dekking EHA, Blokland ML, Wuisman MC, Zuijderduin WM, Koning F, Schweizer JJ. TEFF use in the diet of celiac disease patients in the Netherlands. Journal of Pediatric Gastroenterology and Nutrition 2007;44:245.

69. Koning F. A tertiary twist to the transglutaminase tale. Plos Biology 2007;5:2770-2773.

70. Salentijn EMJ, Pereira A, Angenent GC, van der Linden CG, Krens F, Smulders MJM, Vosman B. Plant translational genomics: from model species to crops. Molecular Breeding 2007;20:1-13.

71. Sanchez E, Alizadeh BZ, Valdigem G, Ortego-Centeno N, Jimenez-Alonso J, de Ramon E, Garcia A, Lopez-Nevot MA, Wijmenga C, Martin J, Koeleman BP. MYO9B gene polymorphisms are associated with autoimmune diseases in Spanish population. Hum Immunol 2007;68:610-615.

72. van Heel DA, Franke L, Hunt KA, Gwilliam R, Zhernakova A, Inouye M, Wapenaar MC, Barnardo MCNM, Bethel G, Holmes GKT, Feighery C, Jewell D, Kelleher D, Kumar P, Travis S, Walters JRF, Sanders DS, Howdle P, Swift J, Playford RJ, McLaren WM, Mearin ML, Mulder CJ, McManus R, McGinnis R, Cardon LR, Deloukas P, Wijmenga C. A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nature Genetics 2007;39:827-829.

73. van Herpen TW, Goryunova SV, Salentijn E, Riley M, Sparks C, van Veelen P, Bosch D, Gilissen LJWJ, Smulders MJM, Jones HD, Shewry PR, Hamer RJ. Alpha-Gliadin Genes from the A, B, and D Genomes of Wheat Contain Different Sets of Celiac Disease Epitopes. In: Lookhart GL, ed. Gluten Proteins 2006. St. Paul, Minnesota: AAAC International, 2007:321-325.

74. van Oort E, Strengman E, Diosdado B, Wapenaar MC, Meijer JWR, Offerhaus JGA, Wijmenga C. Villous atrophy in Celiac disease: uncovering the patho-mechanisms by immunohistochernistry and gene-expression studies. European Journal of Gastroenterology & Hepatology 2007;19:A46-A47.

75. Wapenaar MC, Monsuur AJ, Poell J, van 't SR, Meijer JW, Meijer GA, Mulder CJ, Mearin ML, Wijmenga C. The SPINK gene family and celiac disease susceptibility. Immunogenetics 2007;59:349-357.

76. Weersma RK, Zhernakova A, Nolte IM, Lefebvre C, Rioux JD, Mulder F, van Dullemen HM, Kleibeuker JH, Wijmenga C, Dijkstra G. ATG16L1 and IL23R Are Associated With Inflammatory Bowel Diseases but Not With Celiac Disease in The Netherlands. Am J Gastroenterol 2007;103:621-628.

77. Zhernakova A, Alizadeh BZ, Bevova M, van Leeuwen MA, Coenen MJ, Franke B, Franke L, Posthumus MD, van Heel DA, van der SG, Radstake TR, Barrera P, Roep BO, Koeleman BP, Wijmenga C. Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases. Am J Hum Genet 2007;81:1284-1288.

78. Dekking EHA, van Veelen PA, de Ru A, Kooy-Winkelaar EMC, Groneveld T, Nieuwenhuizen WF, Koning F. Microbial transglutaminases generate T cell stimulatory epitopes involved in celiac disease. Journal of Cereal Science 2008;47:339-346.

79. Festen EA, Zhernakova A, Wijmenga C, Weersma RK. Association of DLG5 variants with gluten-sensitive enteropathy. Gut 2008;57:1027-1028.

80. Franke L, de Kovel CG, Aulchenko YS, Trynka G, Zhernakova A, Hunt KA, Blauw HM, van den Berg LH, Ophoff R, Deloukas P, van Heel DA, Wijmenga C. Detection, imputation, and association analysis of small deletions and null alleles on oligonucleotide arrays. Am J Hum Genet 2008;82:1316-1333.

81. Hopman E, Dekking L, Blokland ML, Wuisman M, Zuijderduin W, Koning F, Schweizer J. Tef in the diet of celiac patients in The Netherlands. Scandinavian Journal of Gastroenterology 2008;43:277-282.

82. Hopman EG, von Blomberg ME, Batstra MR, Morreau H, Dekker FW, Koning F, Lamers CB, Mearin ML. Gluten tolerance in adult patients with celiac disease 20 years after diagnosis? Eur J Gastroenterol Hepatol 2008;20:423-429.

83. Hovhannisyan Z, Weiss A, Martin A, Wiesner M, Tollefsen S, Yoshida K, Ciszewski C, Curran SA, Murray JA, David CS, Sollid LM, Koning F, Teyton L, Jabri B. The role of HLA-DQ8 beta 57 polymorphism in the anti-gluten T-cell response in coeliac disease. Nature 2008;456:534-538.

84. Huibregtse IL, Marietta EV, Rashtak S, Koning F, Rottiers R, David C, van Deventer SJH, Murray JA. Tolerance to gliadin peptides can be restored by enteral administration of Lactococcus lactis bioengineered to deliver the immunodominant antigen to sensitized NOD ABO DQ8 transgenic mice. European Journal of Gastroenterology & Hepatology 2008;20:A59.

85. Hunt KA, Zhernakova A, Turner G, Heap GA, Franke L, Bruinenberg M, Romanos J, Dinesen LC, Ryan AW, Panesar D, Gwilliam R, Takeuchi F, McLaren WM, Holmes GK, Howdle PD, Walters JR, Sanders DS, Playford RJ, Trynka G, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, O'Morain C, Kennedy NP, Kelleher D, Pennington DJ, Strachan DP, McArdle WL, Mein CA, Wapenaar MC, Deloukas P, McGinnis R, McManus R, Wijmenga C, van Heel DA. Newly identified genetic risk variants for celiac disease related to the immune response. Nat Genet 2008;40:395-402.

86. Hunt KA, Franke L, Deloukas P, Wijmenga C, van Heel DA. No evidence in a large UK collection for celiac disease risk variants reported by a Spanish study. Gastroenterology 2008;134:1629-1630.

87. Jungerius BJ, Bakker SC, Monsuur AJ, Sinke RJ, Kahn RS, Wijmenga C. Is MYO9B the missing link between schizophrenia and celiac disease? American Journal of Medical Genetics Part B-Neuropsychiatric Genetics 2008;147B:351-355.

88. Kapoerchan VV, Wiesner M, Overhand M, van der Marel GA, Koning F, Overkleeft HS. Design of azidoproline containing gluten peptides to suppress CD4+ T-cell responses associated with celiac disease. Bioorg Med Chem 2008;16:2053-2062.

89. Koning F. Celiac disease: sandwiched between innate and adaptive immune responses induced by gluten. J Pediatr Gastroenterol Nutr 2008;46 Suppl 1:E8-E9.

90. Koskinen LLE, Korponay-Szabo IR, Viiri K, Juuti-Uusitalo K, Kaukinen K, Lindfors K, Mustalahti K, Kurppa K, Adany R, Pocsai Z, Szeles G, Einarsdottir E, Wijmenga C, Maki M, Partanen J, Kere J, Saavalainen P. Myosin IXB gene region and gluten intolerance: linkage to coeliac disease and a putative dermatitis herpetiformis association. Journal of Medical Genetics 2008;45:222-227.

91. Mitea C, Kooy-Winkelaar Y, van Veelen P, de Ru A, Drijfhout JW, Koning F, Dekking L. Fine specificity of monoclonal antibodies against celiac disease-inducing peptides in the gluteome. American Journal of Clinical Nutrition 2008;88:1057-1066.

92. Mitea C, Havenaar R, Drijfhout JW, Edens L, Dekking L, Koning F. Efficient degradation of gluten by a prolyl endoprotease in a gastrointestinal model: implications for coeliac disease. Gut 2008;57:25-32.

93. Monsuur AJ, de Bakker PI, Zhernakova A, Pinto D, Verduijn W, Romanos J, Auricchio R, Lopez A, van Heel DA, Crusius JB, Wijmenga C. Effective detection of human leukocyte antigen risk alleles in celiac disease using tag single nucleotide polymorphisms. PLoS ONE 2008;3:e2270.

94. Smyth DJ, Plagnol V, Walker NM, Cooper JD, Downes K, Yang JH, Howson JM, Stevens H, McManus R, Wijmenga C, Heap GA, Dubois PC, Clayton DG, Hunt KA, van Heel DA, Todd JA. Shared and distinct genetic variants in type 1 diabetes and celiac disease. N Engl J Med 2008;359:2767-2777.

95. Stepniak D, Wiesner M, de Ru AH, Moustakas AK, Drijfhout JW, Papadopoulos GK, van Veelen PA, Koning F. Large-Scale Characterization of Natural Ligands Explains the Unique Gluten-Binding Properties of HLA-DQ2. J Immunol 2008;180:3268-3278.

96. Tjon JM, Verbeek WH, Kooy-Winkelaar YM, Nguyen BH, van der Slik AR, Thompson A, Heemskerk MH, Schreurs MW, Dekking LH, Mulder CJ, van BJ, Koning F. Defective synthesis or association of T-cell receptor chains underlies loss of surface T-cell receptor-CD3 expression in enteropathy-associated T-cell lymphoma. Blood 2008;112:5103-5110.

97. van den Broeck HC, America AH, Smulders MJ, Gilissen LJ, van dM, I. Staining efficiency of specific proteins depends on the staining method: Wheat gluten proteins. Proteomics 2008.

98. van Herpen TW, Riley M, Sparks C, Jones HD, Gritsch C, Dekking EH, Hamer RJ, Bosch D, Salentijn EM, Smulders MJ, Shewry PR, Gilissen LJ. Detailed analysis of the expression of an alpha-gliadin promoter and the deposition of alpha-gliadin protein during wheat grain development. Ann Bot (Lond) 2008;102:331-342.

99. Wapenaar MC, Monsuur AJ, van Bodegraven AA, Weersma RK, Bevova MR, Linskens RK, Howdle P, Holmes G, Mulder CJ, Dijkstra G, van Heel DA, Wijmenga C. Associations with tight junction genes PARD3 and MAGI2 in Dutch patients point to a common barrier defect for coeliac disease and ulcerative colitis. Gut 2008;57:463-467.

100. Wiesner M, Stepniak D, de Ru AH, Moustakis AK, Drijfhout JW, Papadopoulos GK, van Veelen PA, Koning F. Dominance of an alternative CLIP sequence in the celiac disease associated HLA-DQ2 molecule. Immunogenetics 2008;60:551-555.

101. Wolters VM, Wijmenga C. Genetic background of celiac disease and its clinical implications. Am J Gastroenterol 2008;103:190-195.

102. Wolters VM, Verbeek WHM, Zhernakova A, Onland-Moret C, Schreurs MWJ, Monsuur AJ, Verduijn W, Wijmenga C, Mulder CJJ. The MY09B gene is a strong risk factor for the development of refractory coeliac disease. European Journal of Gastroenterology & Hepatology 2008;20:A32.

103. Dekking L, Koning F, Hosek D, Ondrak TD, Taylor SL, Schroeder JW, Bauer M. Intolerance of celiac disease patients to bovine milk is not due to the presence of T-cell stimulatory epitopes of gluten. Nutrition 2009;25:122-123.

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